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Autocrine and Paracrine Mechanisms in Reproductive by Harry T. Haigler (auth.), Lewis C. Krey, Bela J. Gulyas,

By Harry T. Haigler (auth.), Lewis C. Krey, Bela J. Gulyas, John A. McCracken (eds.)

There is a prov1s10n within the constitution of every examine part of the department of analysis can provide on the nationwide Institutes of overall healthiness that stipulates that "workshops" are to be held periodically to help research part individuals of their value determinations of modern advancements of their fields and to spot destiny demanding situations beneficial of research. The Reproductive Endocrinology examine part was once validated on December thirteen, 1985 to check study supplies and learn education actions when it comes to reproductive endocrinology, together with elements of administration of reproductive endocrine problems and hormonal imbalances as regarding infertility and through being pregnant and puberty, breast melanoma and prostate melanoma. It held its first workshop, entitled, "Autocrine and Paracrine Mechanisms in Reproductive Endocrinology," in October, 1988 in Shrewsbury, MA on the Worcester beginning for Experimental Biology. The lawsuits of this workshop, that are certain herein, mirror the truth that autocrine and paracrine interactions are quickly being permitted as an exhilarating region of analysis via scientists investigating the physiological and biochemical mechanisms of hormone motion within the female and male reproductive platforms. the cloth lined is novel and wide-ranging, extending from theoretical concerns of mechanisms of progress issue motion and the function of telephone cycle degree in picking hormone motion to investigations of autocrine and paracrine interactions in the course of improvement to discussions of the capability scientific ramifications of the elemental learn findings. Such an intensive stock is important for 2 reasons.

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1988). Thus, there is reason to believe that bFGF may be involved in the abnormal growth processes characteristic of BPH. We do not know if prostatic bFGF is a stroma inducer responsible for glandular hyperplasia. , 1988a) suggests that bFGF could have such a role. Is bFGF synthesized by the stoma or the epithelial cells of the prostate? , 1987b). The growth factor is also present in the normal prostate. The cell population(s) responsible for bFGF synthesis in the prostate is not known. Studies to identify the prostatic cell(s) responsible for bFGF are in progress.

Schlessinger J. D. 1984. Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences. Nature (London) 307:521. , Bohlen P. L. 1985. Primary structure of bovine pituitary basic fibroblast growth factor (FGF) and comparison with the amino-terminal sequence of bovine brain acidic FGF. Proc. Natl. Acad. Sci. (USA) 82:6507. Folkman J. and Klagsbrun M. 235:442. 1987. Angiogenic factors. , Mehlman T. and Maciag T. 1986. The characterization of the receptor for endothelial cell growth factor by covalent ligand attachment.

D. 1983. Androgens and estrogens. Their interactions with stroma and epithelium of human benign prostatic hyperplasia and normal prostate. J. Steroid. Biochem. 19:155. , Iwan M. and Igarashi K. 1987. Cloning and expression of cDNA encoding human basic fibroblast growth factor. FEBS Lett. 213:189. , Kontturi M. and Vihko R. 1983. Nuclear androgen receptors in the epithelium and stroma of human benign prostatic hypertrophic glands. Prostate 4:129. C. 1981. A growth factor in extracts of human prostatic tissue.

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