By Meir H. Kryger MD
From Meir H. Kryger, MD, the editor of the definitive source in sleep, rules and perform of Sleep drugs, comes the Atlas of medical Sleep medication. This hugely illustrated atlas will give you a good visible relief to the main entire, authoritative, and up to date info for diagnosing and treating grownup and pediatric sufferers with sleep problems. it's the first atlas that makes use of the recent scoring ideas, and reports how you can use the hot AASM scoring guide that is helping you ranking, interpret, and diagnose sleep issues. every one bankruptcy info the physiologic, medical, morphologic, and investigational features of the entire variety of sleep problems you come upon in daily perform. scientific details is gifted in an easy-to-understand variety, and the combination of colour deals elevated visible advice. Plus, with professional seek advice performance, you will have easy accessibility to the complete textual content on-line, in addition to all the book's illustrations, greater than 20 video clips of sufferer interviews, over forty sleep lab video clips, and two hundred plus polysomnogram fragments at expertconsult.com.
- Includes entry to the full-text on-line at expertconsult.com, in addition to all the book's illustrations, greater than 20 video clips of sufferer interviews, together with narcolepsy and stressed leg syndrome, over forty sleep lab movies, together with obstructive sleep apnea and breathing illnesses, and 2 hundred plus polysomnogram fragments.
- Uses the hot scoring principles, and reports tips on how to use the recent AASM scoring handbook that is helping you ranking, interpret, and diagnose sleep disorders.
- Covers the total variety of sleep problems so that you can diagnose any you spot.
- Features discussions of pediatric stipulations equivalent to pediatric congenital ailments so that you can greater diagnose and deal with this exact staff.
- Contains a wealth of fine quality polysomnograms taken from the newest machines utilized by associations round the world.
- Emphasizes pharmacology and comprises information regarding the newest medicines to be had in addition to these in scientific trials that will help you be certain the simplest and newest drug therapy.
- Uses photos and drawings to successfully describe the body structure of sleep medication to assist make tough options more straightforward to understand.
- Offers a full-color compendium that mixes the body structure of sleep with the correct findings to offer an entire photo of ways sleep impacts each one physique system.
- Uses a constant, easy-to-follow bankruptcy structure that makes reference easy.
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Additional info for Atlas of Clinical Sleep Medicine: Expert consult - Online and Print, 1e
This system is involved in the regulation of many physiological functions including the timing of the production of hormones. The genetics of the circadian system at the cellular level has only recently been understood (Fig. 2-1). The sleep-wake cycle is the most apparent circadian rhythm in humans. 2-1. The genetic mechanism of the circadian clock is similar in many species, from prokaryotic bacteria to fruit flies to mammals. The key mechanism appears to involve an exquisitely timed transcription and translation feedback loop between nuclear gene expression and their protein products.
The sleep-wake cycle is the most apparent circadian rhythm in humans. 2-1. The genetic mechanism of the circadian clock is similar in many species, from prokaryotic bacteria to fruit flies to mammals. The key mechanism appears to involve an exquisitely timed transcription and translation feedback loop between nuclear gene expression and their protein products. In mammals, protein dimers of PER and CRY protein bind to dimers of CLOCK and BMAL1 on the E-box for per genes and inhibit transcription of the PER and CRY genes.
Adapted from Phillipson EA: Regulation of breathing during sleep. 4-6. Respiratory muscle activity during sleep at ambient thermal neutrality (cat). Postural activity of neck and intercostal muscles disappears during the transition from NREMS to REMS. Respiratory activity of intercostal muscles also disappears whereas that of the diaphragm persists. Electrograms: LOC and ROC, left and right occipital cortex; HP, hippocampus; NM, neck muscles; D, diaphragm; IE, m. intercostalis; RM, respiratory movements.