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Alcoholic and Non-Alcoholic Fatty Liver Disease: Bench to by Naga Chalasani, Gyongyi Szabo

By Naga Chalasani, Gyongyi Szabo

This quantity is the 1st textual content to concisely but comprehensively disguise advancements for either alcoholic and nonalcoholic fatty liver sickness in an prepared model. points of those ailments lined within the ebook contain worldwide epidemiology and possibility components, pathogenesis, animal versions, hepatic and extra-hepatic malignancies, therapy versions, and present and rising remedies.

Written by way of specialists within the box, Alcoholic and Non-Alcoholic Fatty Liver affliction: Bench to Bedside is a helpful source for gastroenterologists, pathologists, and hepatologists who deal with sufferers with alcoholic and nonalcoholic fatty liver disease.

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23. Howard AA, Arnsten JH, Gourevitch MN. Effect of alcohol consumption on diabetes mellitus: a systematic review. Ann Intern Med. 2004;140:211–9. 24. Rubin E, Lieber CS. Malnutrition and liver disease– an overemphasized relationship. Am J Med. 1968; 45:1–6. 25. Hashimoto Y, Hamaguchi M, Kojima T, Ohshima Y, Ohbora A, Kato T, Nakamura N, Fukui M. The modest alcohol consumption reduces the incidence of fatty liver in men; a population-based large-scale cohort study. J Gastroenterol Hepatol. 2014;30(3): 546–52.

The Italian Society for the Study of Atherosclerosis (SISA) in 2005 started a research project aimed to study NAFLD. Using ultrasound (US) in nondiabetic subjects, the researchers set out to determine the prevalence of NAFLD, its associated risk factors and prevalence of hypertransaminasemia, and its possible determinants. 78. 0001). 05). 05) were associated with the severity of NAFLD. 01) were also associated with higher ALT. The prevalence of steatosis was reported to be the highest reported in patients with metabolic syndrome.

Genetic variation in Pnpla3 confers susceptibility to nonalcoholic fatty liver disease. Nat Genet. 2008;40:1461–5. Yuan X, Waterworth D, Perry JR, Lim N, Song K, Chambers JC, Zhang W, Vollenweider P, Stirnadel H, Johnson T, Bergmann S, Beckmann ND, Li Y, Ferrucci L, Melzer D, Hernandez D, Singleton A, Scott J, Elliott P, Waeber G, Cardon L, Frayling TM, Kooner JS, Mooser V. Population-based genomewide association studies reveal six loci influencing plasma levels of liver enzymes. Am J Hum Genet.

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