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Advances in Molecular and Cellular Endocrinology, Vol. 1 by Derek Leroith

By Derek Leroith

Traditionally the sphere of endocrine study has consistently been on the leading edge of clinical endeavors. The investigators of those very important breakthroughs in examine were rewarded through a number of Nobel awards. within the box of diabetes by myself, Nobel prizes were presented to researchers who stumbled on insulin, characterised the protein and invented radioimmunoassays utilizing insulin as a paradigm. now not strangely, biomedical researchers have continuously been attracted by means of the endocrine process and different comparable structures of intercellular conversation. during the last 20 years, endocrine study has constructed speedily and tailored smooth molecular and mobile biology thoughts for its particular use. those alterations have allowed researchers within the box to take care of their aspect. hence, endocrine disease-related genes were characterised and mutations in those genes have helped clarify universal and much less universal endocrine problems. Our realizing of the legislation of gene expression has been tremendously stronger via molecular options. In an try and convey investigators brand new with the hot advances during this exploding box we've determined to post a chain entitled Advances in Molecular and mobile Endocrinology. across the world recognized investigators have agreed to take part and their contributions are favored. quantity 1 has all for elements of the hypothalamic-pituitary axis together with GnRH and GH gene rules, molecular points of insulin, insulin-like development components and glucagon. additionally, experiences at the lately cloned calcium receptor and steroid receptor interactions with DNA are awarded.

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E. WONDISFORD Figure 2. Pit-1 splice variants. Thin lines represent Pit-1 splice events. Thick lines represent variant Pit-1 splice events: Pit-lT has the addition of the diagonally shaded area; Pit-113 had the addition of both the diagonally and dot shaded areas. , 1993). In gene transfer studies, D4Pit- 1 inhibits Prl promoter activity and, therefore, it may be a potential mediator ofPrl gene expression (Day and Day, 1994). A third variant, Pit- 1T, has been identified in thyrotroph-derived cells.

LAWSON, D. BELSHAM, S. ERALY,and P. , & Martini, L. (1994). Steroid binding and metabolism in the luteinizing hormone-releasing hormone-producing neuronal cell line GT1-1. Endocrinology 135, 2623-2628. , & Waxman, J. (1990). The partial purification and characterization of GnRH-like activity from prostatic biopsy specimens and prostatic cancer cell lines. J. Steroid Biochem. Molec. Biol. 37, 899-902. D. (1990). Isolation and characterization of the human gonadotropin-releasing hormone gene in the hypothalamus and placenta.

Anterior pituitary gland development in the rat. , 1990). , 1990). Thyrotrophs appear to arise from two independent cell populations in mice. 5, but phenotypically disappears by the day of birth. 5, following the initial expression of Pit-1 in this area. , 1994). A PAR-bZIP protein, thyrotroph embryonic factor (TEF), may be involved in the initial expression of the mouse TSH[3 promoter, as it is first selectively expressed in the rostral tip cells of the anterior pituitary concomitantly with the activation of TSH[3 gene expression.

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