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Adrenal Toxicology by Philip W. Harvey, David J. Everett, Christopher J. Springall

By Philip W. Harvey, David J. Everett, Christopher J. Springall

Despite being considered as the most typical toxicological goal within the endocrine method, the adrenal gland has frequently been overlooked in regulatory checking out. Adrenal Toxicology addresses the elevated curiosity in adrenocortical toxicology and the necessity for a source that makes concepts on hand to envision adrenal endocrine disruption.

Examining present suggestions and the newest developments, Adrenal Toxicology stories the endocrinology, pharmacology, pathology and toxicology of the adrenal gland. this article offers details at the variety of gear and chemical compounds that impact adrenocortical functionality and indicates standardized ways for in vivo and in vitro evaluate. This quantity additionally offers fresh advancements within the molecular mechanisms of toxicity to the adrenal cortex and medulla, and considers environmental adrenal endocrine disruption in sentinel species.

Adrenal Toxicology :

  • reflects the key advancements remodeled the prior decade
  • focuses at the newest study suggestions, together with their makes use of and limitations
  • provides an built-in process for adrenal toxicology evaluation
  • identifies wisdom and knowledge gaps, offering impetus for regulatory consideration

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Sample text

Kapas S, Purbrick A, Hinson JP. Action of opioid peptides on the rat adrenal cortex: Stimulation of steroid secretion through specific mu opioid receptor. J Endocrinol 1995; 144:503–510. Kasperlik-Zaluska AA, Zgliczynski W, Jeske W, et al. ACTH responses to somatostatin, valproic acid and dexamethasone in Nelson’s syndrome. Neuro Endocrinol Lett 2005; 26:709–712. Kau MM, Kan SF, Wang JR, et al. Inhibitory effects of digoxin and ouabain on aldosterone synthesis in human adrenocortical NCI-H295R cells.

Acta Endocrinol 1960; 51:421. Billaudel B, Sutter BCJ. Immediate in vivo effects of corticosterone on glucose induced insulin secretion in rats. J Endocrinol 1982; 95:315–320. Bisson M, Hontela A. Cytotoxic and endocrine disrupting potential of atrazine, diazinon, endosulfan, and mancozeb of adrenocortical steroidogenic cells of rainbow trout exposed in vitro. Toxicol Appl Pharmacol 2002; 180:110–117. Blaha L, Hilscherova K, Mazurova E, et al. Alteration of steroidogenesis in H295R cells by organic sediment contaminants and relationships to other endocrine disrupting effects.

Environ Health Perspect 2006; 114:1497–1501. Barrett AM. Some factors affecting blood ACTH levels. Acta Endocrinol 1960; 51:421. Billaudel B, Sutter BCJ. Immediate in vivo effects of corticosterone on glucose induced insulin secretion in rats. J Endocrinol 1982; 95:315–320. Bisson M, Hontela A. Cytotoxic and endocrine disrupting potential of atrazine, diazinon, endosulfan, and mancozeb of adrenocortical steroidogenic cells of rainbow trout exposed in vitro. Toxicol Appl Pharmacol 2002; 180:110–117.

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